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The referral leaflet from Davies Veterinary Specialists

My cat has been prescribed with an
ACE-INHIBITOR (i.e. benazepril, enalapril, ramipril…)

tabletsACE-inhibitors for cats are used for the treatment of cardiovascular disease, kidney disease with loss of protein in urine, and high blood pressure. When used for the treatment of cardiovascular disease they are usually combined with a diuretic (i.e. furosemide).


What does it do ?

ACE-inhibitors for cats block the action of an enzyme (ACE) responsible for the production of a substance called angiotensin II. This leads to mild dilation of the blood vessels, blocks the bodies attempt to retain sodium and fluids and also counteracts some of the natural mechanisms of adaptation of the cardiovascular system to failure that, although beneficial in the short-term, may become harmful for the heart (i.e. hypertrophy and fibrosis) in the long-term.

Cat at DVS
Side-effects ?

ACE-inhibitors for cats are usually well tolerated. Nevertheless, as is the case with all drugs, a few side-effects may occur. Gastrointestinal disturbances (anorexia, vomit, diarrhea), weakness, low blood pressure, high blood levels of potas-sium, kidney dysfunction.
These signs are more commonly seen shortly after the start of therapy. If you believe your cat is experiencing any of these signs please contact your vet.

Monitoring ?

Before starting an ACE-inhibitor and approximately after 5 days blood pressure measurement and a few blood tests will be advised by your vet/cardiologist in order to assess appropriate kidney function and electrolyte levels and ensure low blood pressure does not occur as a result of treatment. Urine analysis may also be part of the necessary tests. These checks will then be recommended at a regular basis at the time of each control examination.

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